home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410p.zip
/
M94A3196.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
2KB
|
35 lines
Document 3196
DOCN M94A3196
TI Dynamics of CD4 and CD8 cells in blood and lymph nodes of SIVmac239
infected monkeys.
DT 9412
AU Murayama Y; Mukai R; Matui K; Sata T; Takasaka M; Noguchi A; Hassan MA;
Hayami M; Yoshikawa Y; Tsukuba Primate Center for Medical Research, NIH,
Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):131 (abstract no. PA0145). Unique
Identifier : AIDSLINE ICA10/94369379
AB OBJECTIVE: The purpose of the investigation was to analyze the dynamic
interaction between disease progression and lymphocyte subsets in the
blood and lymph nodes (LN). METHODS: The time courses of changes in CD4
subsets and CD4/CD8 ratios were compared in bioptic samples of the LN
and blood from SIVmac239 infected rhesus and cynomolgus monkeys.
RESULTS: Although an apparent decrease of CD4 cells, especially CD29high
CD4 cells, was recognized in the blood. the percentages of CD4 cells and
CD4/CD8 ratios in the LN did not decline but rather increased at several
times after SIV infection. In the LN, the CD29lowCD45RAlow CD4 subset
appeared after virus inoculation and became predominant as the lesions
of the LN progressed. This uncommon CD4 subset was inhibited from
circulating to the periphery, resulting in a deficiency of the CD29high
and CD45RAhigh CD4 cell pool in the LN. DISCUSSION AND CONCLUSIONS:
These qualitative changes of the CD4 cells in the LN might be one of the
reasons for the decline in circulating CD4 cells.
DE Animal Antigens, CD8/BLOOD/*PHYSIOLOGY CD4-CD8 Ratio Lymph
Nodes/*IMMUNOLOGY Macaca fascicularis Macaca mulatta Simian Acquired
Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY SIV/*IMMUNOLOGY
T-Lymphocyte Subsets/IMMUNOLOGY T-Lymphocytes/*IMMUNOLOGY T4
Lymphocytes/*IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).